Jan Matthijs Moll of the Erasmus Medical Center, Dept. Of Urology in Rotterdam, Netherlands. Guys with castration resistant prostate tumor are a difficult group to treat. Although metastatic prostate cancer may respond originally well to androgen ablation therapy, castration resistance develops within 3 years. Though circulating testosterone levels are low in these patients Even, the androgen receptor reactivates, which indicates the AR remains a significant target in CRPC. The Rotterdam-based group has demonstrated that transformation of adrenal androgens into testosterone previously, than intratumoural de novo steroidogenesis rather, is the major way to obtain testosterone in CRPC tumours.The dosages we used were equal to what you’d enter about 1,000 bottles of red wine a day, Turner noted. James Hendrix, director of global science initiatives for the Alzheimer’s Association, said the results are encouraging and warrant larger studies. But he agreed that only time will tell if resveratrol can help slow the dementia procedure. Scientists first became thinking about resveratrol while an Alzheimer’s therapy predicated on calorie restriction analysis, Turner said. In animals, reduced-calorie diets seem to stall the consequences of aging and boost longevity – – at least partly because calorie restriction boosts activity in a gene called SIRT1. It turns out that resveratrol activates SIRT1 also. So resveratrol essentially mimics calorie restriction, Turner said.