Still, lifestyle after loss of life has been quite good for most of these stars who’ve lead very healthy, effective lives. Need to know who offers been hoaxed? Have a look at our slide show.. Adam Sandler Death Rumors Are Totally True Adam Sandler is definitely dead. It’s true. OK, it’s totally not true. He didn’t die in a plane crash nor was his lifeless body dragged from a Switzerland mountain. Not lifeless this week are Aretha Franklin and Charlie Sheen Also, although Franklin has been dealing with an unspecified medical procedures. Sandler and organization are simply the latest in a long line of celebrities to fall victim to death hoax rumors, some of which stretch back generations .Although the function of MKRN3 isn’t well understood, and the mechanism where MKRN3 mutations result in early activation of the central reproductive axis aren’t yet known, our genetic data are sufficiently compelling and statistically strong to invoke a causative role for MKRN3 in central precocious puberty. The inheritance pattern in the affected families is in keeping with the expression of MKRN3 from the paternally inherited allele only. For instance, Patient II-1 in Family A inherited the mutant MKRN3 allele from his mom; because this allele was silenced, he didn’t have the central precocious puberty phenotype. Sufferers II-1 in Families C, D, and E were asymptomatic heterozygous carriers of deleterious MKRN3 mutations apparently, but since we were not able to obtain reliable pubertal DNA or histories from their parents, the parental source of their mutations is unknown.