By that right time, Akorn programs to have products filed out of each of the rest of the manufacturing facilities. Q: How come Akorn projecting a considerable upsurge in R&D costs? A: There are three primary factors adding to the elevated costs: 1) the Generic Drug Consumer Fee Act charges associated with the projected 35-40 abbreviated new drug software filings for 2014; 2) the expense of bio-equivalence studies connected with high-value products; and 3) the elevated internal R&D costs caused by the growth of Akorn's R&D infrastructure, the costs associated with product development and global filings out of Akorn India, and the inclusion of Hi-Tech in the 2014 Outlook.But our study didn’t show a statistically significant role for alcohol in guarding against stroke. While there does seem to be a small window that light drinking is connected with lower risk, it is critical to note that this home window is smaller than it is for heart disease and for that reason you cannot basically extrapolate between the two. Mukamal notes that red wine appeared to offer slightly even more protection than other styles of alcohol, with red-wine drinkers shown to be at 23 % lower risk of ischemic stroke. Weighed against other styles of alcohol, red wine was connected with a step-wise lower threat of ischemic stroke, according to Mukamal. This is curious, because among this human population of men, red wine is not associated with a lower risk of heart disease any longer than any other kind of alcohol, so it’s unclear why this might end up being the case with stroke.