However, a more substantial sample may have permitted better discrimination between effects in the subgroups of individuals. 25 Operators at all centers had the opportunity to participate in training meetings organized through the study, where cases or controversial issues could be discussed. Some issues might affect the generalizability of our findings. As in large trials of intravenous t-PA,1 the demonstration of vessel occlusion had not been a precondition for inclusion in our trial. There are many alternative approaches, a few of which are already used in clinical practice, to select patients for endovascular treatment.We then analyzed the info from this subject matter with data from the subjects with the hypersensitivity syndrome together. Maculopapular Exanthema The group with maculopapular exanthema contains 106 subjects: 57 who were recruited through the Liverpool collaborators and 49 who were recruited through the EPIGEN consortium. Maculopapular exanthema was thought as rash without systemic symptoms that needed the discontinuation of carbamazepine within three months after the initiation of drug therapy.