The American Lung Association Asthma Clinical Research Centers: Efficacy of Esomeprazole for Treatment of Poorly Controlled Asthma Gastroesophageal reflux and asthma, both of which are normal conditions, coexist in the same patient often. Persons with asthma are particularly susceptible to asymptomatic gastroesophageal reflux. Esophageal pH-monitoring studies show that 32 to 84 percent of persons with asthma have unusual acid reflux disorder,1-5 and about 50 percent of patients with asthma who’ve reflux have no symptoms online .3,6-8 However, the role of gastroesophageal reflux in the advancement or persistence of asthma symptoms isn’t known.9 Moreover, the causal relationship between gastroesophageal and asthma reflux is complex.
In a further analysis, we included as covariates all of the baseline clinical characteristics that were assessed in the study patients. For the next primary end stage , we assessed the treatment effect with a logistic-regression model to calculate chances ratios, with and without adjustment for all baseline covariates. We adjusted the overall significance level of 0.05 to take into account the inclusion of two main end points. The first was examined at a two-sided significance degree of 0.04, and the second , at a two-sided significance degree of 0.01. Thus, self-confidence intervals of 96 percent and 99 percent had been calculated for the initial and the next primary end factors, respectively.