Safety In the combination group, 59 percent and 57 percent of the patients received at least four doses of nivolumab and ipilimumab, respectively; in the ipilimumab monotherapy group, 70 percent of the patients received at least four doses of ipilimumab . The rate of treatment-related adverse events, as assessed by the investigators, was 91 percent in the mixture group and 93 percent in the ipilimumab-monotherapy group . Drug-related adverse events of grade three or four 4 were reported more frequently in the combination group than in the ipilimumab-monotherapy group ; in sufferers who received the combination routine, the onset of all adverse events occurred through the combination phase as opposed to the maintenance stage.However, only married women seemed to enjoy this benefit happily; unhappily married women did not show the exaggerated drop-off in cortisol after a occupied time. The investigators said additional research is required to understand precisely how marital satisfaction influences your body’s stress response procedure. But they think that a natural inclination to socially withdraw after a demanding day may help explain why guys and happily married women demonstrated the exaggerated decline in cortisol after busier times at the job while unhappily married females did not. ‘They’re coming house from a busy time and rather than having some time to unwind and loosen up and have a spouse picking up the load of setting the table, getting dinner going, signing forms for the small children, these women may need to to launch back to another stressful routine immediately,’ Repetti said.