Eran Leitersdorf.

Gregory G. Schwartz, M male extra .D., Ph.D., Anders G. Olsson, M.D., Ph.D., Markus Abt, Ph.D., Christie M. Ballantyne, M.D., Philip J. Barter, M.D., Ph.D., Jochen Brumm, Ph.D., Bernard R. Chaitman, M.D., Ingar M. Holme, Ph.D., David Kallend, M.B., B.S., Lawrence A. Leiter, M.D., Eran Leitersdorf, M.D., John J.V. McMurray, M.D., Hardi Mundl, M.D., Stephen J. Nicholls, M.B., B.S., Ph.D., Prediman K. Shah, M.D., Jean-Claude Tardif, M.D., and R. Scott Wright, M.D. For the dal-OUTCOMES Investigators: Effects of Dalcetrapib in Patients with a Recent Acute Coronary Syndrome High-density lipoproteins participate in the procedure of cellular cholesterol efflux and could have additional protective results against atherothrombosis.1 An inverse association between degrees of HDL cholesterol and incident events of coronary heart disease has been shown in observational studies2,3 and persists in most post hoc analyses and meta-analyses of trials of statin therapy for sufferers with cardiovascular risk factors, chronic coronary disease, or recent acute coronary syndrome.4-10 However, it remains uncertain whether pharmacologic intervention that raises HDL cholesterol levels outcomes in reduced cardiovascular risk.11-16 Moreover, changes in HDL cholesterol levels might not reflect adjustments in the physiologic features of HDLs.17 Cholesteryl ester transfer proteins mediates the transfer of cholesteryl ester from HDLs to atherogenic lipoprotein particles containing apolipoprotein B, such as for example low-density lipoprotein .

The 95 percent confidence interval for the hazard ratio is presented. Chi-square assessment was used for rate of recurrence comparisons. All reported subgroup analyses were prespecified. Periprocedural myocardial infarction was described in the protocol as a troponin level or a creatine kinase MB level 6 hours after the treatment that was more than 3 times the upper limit of the normal range.15 Prespecified sensitivity analyses using more stringent definitions of type 4a myocardial infarction were performed. All testing had a two-sided significance level of 5 percent and were performed with the use of SAS software, version 9.2 . Results Features of the Patients From 2009 through January 2011 January, we enrolled 2440 individuals, of whom 1227 were assigned to the conventional-treatment group and 1213 to the monitoring group .