Eugenia Oviedo-Joekes.

Eugenia Oviedo-Joekes, Ph .D., Suzanne Brissette, M.D., David C. Marsh, M.D., Pierre Lauzon, M.D., Daphne Guh, M.Sc., Aslam Anis, Ph.D., and Martin T. Schechter, M.D., Ph.D.: Diacetylmorphine versus Methadone for the Treatment of Opioid Addiction Opioid dependence, most manifested as heroin dependence commonly, is certainly a chronic relapsing condition1 that is estimated to affect more than 1 million persons in North America.2,3 The risks of opioid dependence include fatal overdoses, infections , social disintegration, violence, and crime.

There is no evidence against the proportional-hazards assumption for any final end point. Results for the end points of survival free from medical progression and survival free from distant metastases are provided in the Supplementary Appendix. Discussion A previous trial of the treating locally advanced prostate cancer 1,2 showed that radiotherapy plus three years of androgen suppression in comparison with radiotherapy alone provided a benefit regarding overall survival. We conducted the current trial to determine whether overall survival after radiotherapy plus six months of androgen suppression is usually inferior compared to radiotherapy plus 3 years of androgen suppression.8 percent and 1.5 percent, respectively).