The median overall survival has not however been reached; the preliminary 12-month general survival price was 66 percent . Data from 15 of the 20 individuals in the cohort had been censored for overall survival estimates. At the time of the cutoff date, 5 sufferers were still getting therapy. In total, 6 of the 14 individuals had a reply , for a response rate of 43 percent . Disease regression was observed in the majority of patients , and improvement in disease-related symptoms was noticed across all degrees of tumor regression. With a median treatment length of 5.9 months , zero sufferers had progressive disease while receiving treatment.* IPL Photofacial: IPL is a fast and effective method of reducing pigmentation and lines and wrinkles. It is a thirty minutes treatment where light pluses are passed through pores and skin. As the light penetrates deeper, it stimulates fibroblasts to create fresh collagen. Outcomes of the procedure are good, but generally there are dangers like burns and marks. Moreover, the procedure is expensive. Side-effects of aggressive skin lightening creams Despite various options, people use aggressive lightening creams for reducing the dark pigmentations and spots. However, these creams could be damaging for your skin.