Mutations in this gene are connected with retinoblastoma , an embryonic malignant neoplasm of retinal origin that’s associated with a minimal risk of osteosarcoma.30 The expert panel considered the chance of retinoblastoma to be negligible because of this patient, since the age had been reached by him of 8 years, but decided that it had been important to inform the parents of the tiny chance that a sudden, painful swelling of the limbs could be due to an osteosarcoma and they should consult an oncologist at the first sign of such swelling. No further incidental findings were encountered. In conclusion, our study demonstrates exome sequencing can be used as a diagnostic process of patients with serious intellectual disability of unidentified cause.‘In most instances, nothing will happen,’ Gozal stated. ‘But it’s important for parents to be aware that tonsillectomy can have [complications], like any other surgical procedure.’ Anywhere from 1 % to 5 % of kids have obstructive sleep apnea, a problem where tissues in the throat constrict while asleep, causing repeated pauses in breathing. Loud snoring is the most obvious indicator, but daytime sleepiness and attention complications are also warning flag.