Joep de Ligt.

Mutations in genes with a known association with intellectual disability were considered to be a reason behind intellectual disability when the mutations were predicted to be pathogenic by the majority of 3 prespecified in silico analyses and when they occurred in individuals with phenotypes similar to those described in other individuals with mutations in these genes. Mutations were thought to affect candidate genes that had not previously been implicated in intellectual disability when the mutations were predicted to end up being pathogenic by nearly all three prespecified in silico analyses, showed a web link to brain or embryonic advancement in an assessment of the literature, and met in least two of the following criteria: evolutionary conservation, brain-expression design, excellent results on GO-term evaluation, or implication based on animal models .Basic safety and Efficacy in the Active-Control Study The primary outcome for efficacy was confirmed by central adjudication in 26 patients in the dabigatran group and in 18 patients in the warfarin group . The overall hazard ratio with dabigatran for period to the first primary-outcome event was 1.44 , and the chance difference at 1. 5 years was 0.50 to at least one 1.25) .), calculated by using the meta-analytic approach. In a Cox regression analysis of pooled individual data, the hazard ratio was 1.47 . Dabigatran thus met the requirements for noninferiority to warfarin with regard to the prevention of recurrent or fatal venous thromboembolism .