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Apart from 3 counties or districts, all the centers were open a day a full day. This study was approved by the institutional review board of the Beijing CDC. Surveillance for Adverse Events Passive surveillance for adverse events was conducted through the Adverse Event Pursuing Immunization reporting system, which was established in 2005 for the surveillance of vaccine safety following licensure. Anyone, including vaccine recipients and health care providers, can record a suspected AEFI to the Beijing CDC. Based on the guidelines for the evaluation of adverse events by the State Food and Drug Administration of China, intensity was graded on a scale of just one 1 to 4 as follows: 1, moderate symptoms that usually do not affect daily activities; 2, moderate symptoms that occasionally interfere with daily activities; 3, serious symptoms that affect daily activities or require medicine or additional treatment; and 4, symptoms which are potentially life-threatening or necessitate a stop by at an emergency department or hospitalization.