The main academic investigator also designed the scholarly study and wrote the first draft of the manuscript. Data were collected by a contract research corporation . All authors vouch for the veracity and completeness of the data and data analyses and for the fidelity of the report to the protocol , approved the final version, and made a decision to submit the manuscript for publication. All authors possess confidentiality agreements with Pfizer. The study was approved by the institutional review board or independent ethics committee for each center. All sufferers provided written educated consent. Study Patients Our 8-week multicenter, randomized, double-blind, placebo-controlled trial was conducted at 51 centers in 17 countries from January 2009 through September 2010.The full total fat of mucus created was assessed with an analysis-of-variance model . Boundary-crossing probabilities had been prespecified for the interim and final analyses of the primary end point to control the entire type I error price of 0.05; no additional adjustments for multiple testing were made. Other end factors were analyzed by using similar models. Two exploratory sensitivity analyses were performed to verify that the efficacy results were because of a treatment impact rather than prophylactic effect. The initial analysis excluded individuals with quantitative RT-PCR viral-load results of 0 for all nasal-clean samples collected during quarantine; the next analysis excluded individuals with quantitative RT-PCR viral-load results of 0 for all nasal-wash samples gathered before treatment.